HBOT for Lyme Disease: A New Path to Recovery

Published on
June 22, 2026

The Challenge of Chronic Lyme Disease

Lyme disease is the most common vector-borne illness in the United States, with an estimated 476,000 new cases diagnosed each year. While many patients recover with standard antibiotic treatment, a significant percentage develop persistent symptoms known as Post-Treatment Lyme Disease Syndrome or chronic Lyme disease. These symptoms can include debilitating fatigue, widespread joint and muscle pain, cognitive difficulties known as Lyme brain fog, nerve pain, and sleep disturbances.

For patients who continue to suffer despite antibiotic treatment, finding effective therapies can be a long and frustrating journey. Hyperbaric oxygen therapy is emerging as a promising complementary treatment that addresses the underlying mechanisms driving chronic Lyme symptoms.

How HBOT Targets Lyme Disease Mechanisms

The Borrelia burgdorferi bacterium that causes Lyme disease is an anaerobic organism, meaning it thrives in low-oxygen environments. HBOT creates a high-oxygen environment that is inhospitable to these bacteria. By saturating tissues with oxygen at pressures 2 to 3 times normal, HBOT helps the immune system fight persistent infection more effectively.

Beyond its antimicrobial effects, HBOT addresses the chronic inflammation that drives many Lyme symptoms. It modulates the inflammatory response, reduces neuroinflammation contributing to brain fog, stimulates immune function, promotes tissue repair in damaged joints and nerves, and enhances mitochondrial function to combat fatigue at the cellular level. HBOT also mobilizes stem cells that accelerate the healing process.

What Patients Experience

Many chronic Lyme patients report noticeable improvements in energy levels, mental clarity, and pain reduction during their HBOT treatment course. Some patients experience a temporary increase in symptoms early in treatment, often called a Herxheimer reaction, as the body clears bacterial debris. Our physicians monitor for this closely and adjust treatment as needed. Read more about what to expect at your first HBOT session.

Treatment at National Hyperbaric

Our Lyme disease protocol is tailored to each patient's symptom profile and treatment history. Protocols typically involve 20 to 40 sessions. Our physicians, including Dr. Allan Spiegel and Dr. Montana, work alongside your infectious disease specialist or Lyme-literate doctor to ensure a coordinated approach to your care. Learn about all the conditions we treat and explore the published research supporting HBOT for Lyme disease.

If chronic Lyme disease has been holding you back, contact National Hyperbaric for a free consultation to explore whether HBOT could be part of your recovery plan. For out-of-state patients, we offer travel for treatment support. Visit our cost and insurance page for coverage details.